1445475-53-5

1445475-53-5 structure

Name: Isograndifoliol
Chemical Name: Isograndifoliol
CAS Number: 1445475-53-5
Molecular Formula: C₁₉H₂₆O₃
Molecular Weight: 302.41
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2023-01-29 15:11:45
Modify Date: 2024-04-05 17:04:47
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases[1][2][3].

Name	Isograndifoliol

Description	Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	AChE:342.9 μM (IC50) BChE:0.9 μM (IC50)
In Vitro	Isograndifoliol 对氯化钾或去甲肾上腺素预缩大鼠主动脉环具有剂量依赖性的血管松弛作用，EC50值为 36.36-74.51 μg/mL[2]。 Isograndifoliol 对 HL-60 细胞有较强的抑制活性，IC50 值为 0.33 μM[3]。
References	[1]. Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21(12):4475. [2]. Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348. [3]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11(2):159-61.

Molecular Formula	C₁₉H₂₆O₃
Molecular Weight	302.41