2,3-Dihydrophthalazine-1,4-dione
Names
[ CAS No. ]:
1445-69-8
[ Name ]:
2,3-Dihydrophthalazine-1,4-dione
[Synonym ]:
1,4-Phthalazinedione
1,4-DIHYDROXYPHTHALAZINE
Phthalohydrazide
N,N'-Phthaloylhydrazine
2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE
1,4-phthalazinediol
2,3-dihydrophthalazine-1,4-dione
2,3-Dihydro-1,4-phthalazinedione
Phthalhydrizide
PHTHALHYDRAZINE
PHTHALIC HYDRAZIDE
PHTALYLHYDRAZINE
phthalazine-1,4-diol
Phthalodihydrazide
1,4-Phthalazinedione, 2,3-dihydro-
2,3-Dihydro-1,4-phthalazinedione ; Phthalhydrazine
EINECS 215-893-4
MFCD00006888
1,4-Ketophthalazine
Phthaloylhydrazine
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
523.5ºC at 760 mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C8H6N2O2
[ Molecular Weight ]:
162.145
[ Flash Point ]:
270.4ºC
[ Exact Mass ]:
162.042923
[ PSA ]:
65.72000
[ LogP ]:
0.57
[ Vapour Pressure ]:
1.41E-11mmHg at 25°C
[ Index of Refraction ]:
1.587
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TH8890080
- CHEMICAL NAME :
- 1,4-Phthalazinedione, 2,3-dihydro-
- CAS REGISTRY NUMBER :
- 1445-69-8
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H6-N2-O2
- MOLECULAR WEIGHT :
- 162.16
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 327,237,1994 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 700 mg/kg
- SEX/DURATION :
- female 7 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 327,237,1994
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
TH8890080
[ HS Code ]:
2933990090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Biomed. Biochim. Acta 47(4-5) , 423-33, (1988)
2,3-Dihydrophthalazine-1,4-dione effectively lowers serum levels of cholesterol and triglycerides in Sprague Dawley rats after two weeks, after which the cholesterol levels continued to decline. The m...
Anti-inflammatory activity of 2,3-dihydrophthalazine-1,4-diones in CF1 mice.Int. J. Tissue React. 18(2-3) , 47-55, (1996)
2,3-Dihydrophthalazine-1,4-diones were observed to be potent anti-inflammatory agents as well as capable of protecting against endotoxin shock in mice at 8 mg/kg i.p. These agents blocked both locally...
The anti-neoplastic activity of 2,3-dihydrophthalazine-1,4-dione and N-butyl-2,3-dihydrophthalazine-1,4-dione in human and murine tumor cells.Anticancer Drugs 3(1) , 55-62, (1992)
2,3-Dihydrophthalazine-1,4-dione derivatives demonstrated potent cytotoxicity against the growth of murine leukemia cells and human single cell suspension, i.e. Tmolt3 leukemia and HeLa-S3, as well as...