dihydralazine
Names
[ CAS No. ]:
484-23-1
[ Name ]:
dihydralazine
[Synonym ]:
1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone
Dihydralazin
Nepresol
1,4-dihydrazinophthanazine
1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone, (1Z,4Z)-
1,4-Dihydrazinophthalazine
Nepresolin
Dihydrallazine
Dihydrallazin
4-Hydrazino-1-hydrazono-1,2-dihydrophthalazine
phthalazine, 1,4-bis(hydrazino)-
Phthalazine, 1,4-bis(hydrazinyl)-
1,4-dihydrazinophtalazine
(1Z,4E)-1,4-Dihydrazono-1,2,3,4-tetrahydrophthalazine
Nepressol
Hypopresol
1,4-bis(hydrazino)phthalazine
1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone, (1Z,4E)-
(1Z,4Z)-1,4-Dihydrazono-1,2,3,4-tetrahydrophthalazine
Ophthazin
dihydralazine
1,4-dihydrazinylphthalazine
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
419.9±28.0 °C at 760 mmHg
[ Melting Point ]:
180ºC
[ Molecular Formula ]:
C8H10N6
[ Molecular Weight ]:
190.205
[ Flash Point ]:
207.7±24.0 °C
[ Exact Mass ]:
190.096695
[ PSA ]:
108.34000
[ LogP ]:
0.73
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.810
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TH8849900
- CHEMICAL NAME :
- Phthalazine, 1,4-dihydrazino-
- CAS REGISTRY NUMBER :
- 484-23-1
- BEILSTEIN REFERENCE NO. :
- 0183442
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C8-H10-N6
- MOLECULAR WEIGHT :
- 190.24
- WISWESSER LINE NOTATION :
- T66 CNNJ BMZ EMZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 106 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 250 ug/kg
- SEX/DURATION :
- female 32 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 125 ug/tube
- REFERENCE :
- ABPLAF Acta Biochimica Polonica. (Polish Biochemical Society, Posteura 3, 01-093 Warsaw, Poland) V.1- 1954- Volume(issue)/page/year: 42,291,1995
Safety Information
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%