Anti-inflammatory activity of 2,3-dihydrophthalazine-1,4-diones in CF1 mice.

L Butner, Y Huang, E Tse, I H Hall

Index: Int. J. Tissue React. 18(2-3) , 47-55, (1996)

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Abstract

2,3-Dihydrophthalazine-1,4-diones were observed to be potent anti-inflammatory agents as well as capable of protecting against endotoxin shock in mice at 8 mg/kg i.p. These agents blocked both locally- and centrally-induced pain at 8 mg/kg i.p. In part they appear to mediate their effects due to their ability to suppress the release of cytokines such as TNF alpha and IL-1 from macrophages, as well as the binding of these cytokines to high-affinity receptors on target cells involved in the inflammation process. Lysosomal hydrolytic enzymes as well as 5'-lipoxygenase activities were reduced by the agents.