UCSF924

Names

[ Name ]:
UCSF924

Biological Activity

[Description]:

UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

[Target]

Ki: 3 nM (dopamine D4 receptor)[1]

[References]

[1]. Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂N₂O₂

[ Molecular Weight ]:
322.40

Related Compounds

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