U-73343

Names

[ Name ]:
U-73343

[Synonym ]:
2,5-Pyrrolidinedione, 1-[6-[[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-
1-(6-{[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino}hexyl)-2,5-pyrrolidinedione
MFCD00211221
IN1024
1-(6-{[3-methoxyestra-1,3,5(10)-trien-17-yl]amino}hexyl)pyrrolidine-2,5-dione
1-[6-({5-methoxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-14-yl}amino)hexyl]pyrrolidine-2,5-dione
1-(6-((17β-3-Methoxyestra-1,3,5(10)-triene-17-yl)amino)hexyl)-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-(6-(((17β)-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-

Biological Activity

[Description]:

U-73343, an inhibitor of PLC (putative phospholipase C)-dependent processes, is an analog of U-73122 and can be used as a negative control[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Others

[References]

[1]. Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
641.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₄₂N₂O₃

[ Molecular Weight ]:
466.66

[ Flash Point ]:
341.8±31.5 °C

[ Exact Mass ]:
466.319550

[ PSA ]:
58.64000

[ LogP ]:
5.49

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

Articles

Mechanisms of the sarcoplasmic reticulum Ca2+ release induced by P2X receptor activation in mesenteric artery myocytes.

Pharmacol. Rep. 66(3) , 363-72, (2014)

ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that con...

G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels.

Pflugers Arch. 466(8) , 1635-46, (2014)

TRPC5 is an ion channel permeable to monovalent and divalent cations that is widely expressed in different tissues. Although implicated in the control of neurite extension and in the growth cone morph...

Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.

Eur. J. Pharmacol. 514(2-3) , 151-8, (2005)

Bombesin receptors are mainly divided into two subtypes: BB1 receptor (neuromedin B-preferring receptor) and BB2 receptor [gastrin-releasing peptide (GRP)-preferring receptor]. Previously, we reported...