RSC 133

Names

[ Name ]:
RSC 133

[Synonym ]:
3-{[(2E)-3-(1H-Indol-3-yl)-2-propenoyl]amino}benzamide
Benzamide, 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-
RSC 133

Biological Activity

[Description]:

RSC133 exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. RSC133 effectively facilitates reprogramming of human somatic cells to pluripotent stem cells and supports the maintenance of an undifferentiated state of human pluripotent stem cells[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

Signaling Pathways >> Epigenetics >> DNA Methyltransferase

[References]

[1]. Lee J, et al. A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
653.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₅N₃O₂

[ Molecular Weight ]:
305.331

[ Flash Point ]:
349.1±31.5 °C

[ Exact Mass ]:
305.116425

[ LogP ]:
2.53

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.771

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H411

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds

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