LY 231617

LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM[1]. LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion[1].

LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats[2]. LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion[2]. Animal Model: Male Wistar rats four-vessel occlusion[2] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg 30 minutes before occlusion Result: Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion. Animal Model: Male Wistar rats four-vessel occlusion[2] Dosage: 20 mg/kg Administration: Intravenous injection ; 20 mg/kg 30 minutes after occlusion Result: Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.