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  • DC Chemicals Limited
  • China
  • Product Name: Ly-231617
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

141545-89-3

141545-89-3 structure
141545-89-3 structure
  • Name: LY 231617
  • Chemical Name: 2,6-ditert-butyl-4-(ethylaminomethyl)phenol,hydrochloride
  • CAS Number: 141545-89-3
  • Molecular Formula: C17H30ClNO
  • Molecular Weight: 299.87900
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-08-17 21:34:45
  • Modify Date: 2024-01-24 09:05:10
  • LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease[1][2].

Name 2,6-ditert-butyl-4-(ethylaminomethyl)phenol,hydrochloride
Description LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease[1][2].
Related Catalog
In Vitro LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM[1]. LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion[1].
In Vivo LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats[2]. LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion[2]. Animal Model: Male Wistar rats four-vessel occlusion[2] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg 30 minutes before occlusion Result: Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion. Animal Model: Male Wistar rats four-vessel occlusion[2] Dosage: 20 mg/kg Administration: Intravenous injection ; 20 mg/kg 30 minutes after occlusion Result: Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.
Boiling Point 316.4ºC at 760 mmHg
Molecular Formula C17H30ClNO
Molecular Weight 299.87900
Flash Point 14.3ºC
Exact Mass 299.20200
PSA 32.26000
LogP 5.28960
Vapour Pressure 0.000222mmHg at 25°C
Index of Refraction 1.503