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PF 06465469

Names

[ CAS No. ]:
1407966-77-1

[ Name ]:
PF 06465469

[Synonym ]:
pf-06465469

Biological Activity

[Description]:

PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk

[Target]

IC50: 2 nM (ITK)[1]


[References]

[1]. Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H33N7O2

[ Molecular Weight ]:
523.63

[ Exact Mass ]:
523.27000

[ PSA ]:
119.03000

[ LogP ]:
5.70120

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport


Related Compounds