Bacitracin zinc

Names

[ Name ]:
Bacitracin zinc

[Synonym ]:
Bacitracin zinc
EINECS 215-787-8
L-isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9-
Bacitracin zinc salt
MFCD00130598
L-isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-15-(1-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-12-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclopentacos-21-yl]-, zinc salt (1:1)
L-Isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9- (1H-imidazol-5-ylmethyl)-15-(1-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-12-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclopentacos-21-yl]-, zinc salt (1:1)
Bacitracin (Zinc)

Biological Activity

[Description]:

Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.Target: AntibacterialBacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis [1, 2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. Murphy, T., et al., Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. J Biotechnol, 2007. 131(4): p. 397-403.

[2]. Karala, A.R. and L.W. Ruddock, Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J, 2010. 277(11): p. 2454-62.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
250 ºC (dec.)

[ Molecular Formula ]:
C₆₆H₁₀₁N₁₇O₁₆SZn

[ Molecular Weight ]:
1488.101

[ Exact Mass ]:
1485.677002

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
5.1 g/L (28 ºC)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Clearance of nasal Staphylococcus aureus colonization with triple antibiotic ointment.

Journal. of. Drugs in. Dermatology. 11(12) , 1490-2, (2012)

The prevalence of Staphylococcus aureus colonization of healthcare workers is reported at 30%, with colonization rates for methicillin-resistant S aureus (MRSA) reported between 2.0% and 8.5% among in...

Role of topical antibiotic prophylaxis in prevention of bacterial translocation into upper trachea in nasally intubated patients undergoing tonsillectomies.

Int. J. Pediatr. Otorhinolaryngol. 77(2) , 270-4, (2013)

The human oropharynx and nasopharynx are home of different bacteria and fungi. The initial sterile endotracheal tube (ETT) transfers mechanically the bacteria from the nasopharynx and oropharynx to th...

Alteration of bile acid metabolism in pseudo germ-free rats [corrected].

Arch. Pharm. Res. 35(11) , 1969-77, (2012)

To characterize the impact of gut microbiota on host bile acid metabolism, we investigated the metabolic profiles of oxysterols and bile acids (BAs) in a conventional rat model (SD) (n=5) and its pseu...

Related Compounds

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