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BRD6688

Names

[ CAS No. ]:
1404562-17-9

[ Name ]:
BRD6688

[Synonym ]:
N-[2-Amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide
1-Pyrrolidinecarboxamide, N-[2-amino-5-(4-pyridinyl)phenyl]-

Biological Activity

[Description]:

BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Research Areas >> Neurological Disease
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC2


[References]

[1]. Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6(1):804-815.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
528.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H18N4O

[ Molecular Weight ]:
282.340

[ Flash Point ]:
273.3±30.1 °C

[ Exact Mass ]:
282.148071

[ LogP ]:
0.84

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.679

Related Compounds