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glucagon receptor antagonists-4

Names

[ CAS No. ]:
1393124-08-7

[ Name ]:
glucagon receptor antagonists-4

[Synonym ]:
N-{4-[(1S)-1-{3,5-Dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy}butyl]benzoyl}-β-alanine
β-Alanine, N-[4-[(1S)-1-[3,5-dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy]butyl]benzoyl]-
glucagon receptor antagonists-4
PF-06291874

Biological Activity

[Description]:

Glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. It displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Research Areas >> Metabolic Disease

[References]

[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8.

[2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.


[Related Small Molecules]

Exenatide acetate salt | Adomeglivant | Exendin Fragment 9-39 | MK 0893 | GLP-1(7-36) Acetate | GLP-1 (7-37) | Lixisenatide | LGD-6972 | Taspoglutide | GRA Ex-25 | GLP-1 receptor agonist 1 | GLP-1 receptor agonist-1

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
675.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H28F3N3O4

[ Molecular Weight ]:
503.513

[ Flash Point ]:
362.0±31.5 °C

[ Exact Mass ]:
503.203186

[ LogP ]:
5.44

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.563

Related Compounds