Glucagon receptor antagonists-5

Names

[ CAS No. ]:
2200274-63-9

[ Name ]:
Glucagon receptor antagonists-5

Biological Activity

[Description]:

Glucagon receptor antagonists-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM). Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM)[1].

[Target]

Ki: 32 nM (glucagon receptor)[1]


[References]

[1]. Xu G, et al. Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126668.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H29ClF3N3O3

[ Molecular Weight ]:
572.02

Related Compounds