Adomeglivant

Names

[ Name ]:
Adomeglivant

[Synonym ]:
3-(4-{(1S)-1-[(4'-tert-butyl-2,6-dimethylbiphenyl-4-yl)oxy]-4,4,4-trifluorobutyl}benzamido)propanoic acid
adomeglivant
UNII:74Z5ZL2KVG
74Z5ZL2KVG
β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]-
N-{4-[(1S)-1-{[2,6-Dimethyl-4'-(2-methyl-2-propanyl)-4-biphenylyl]oxy}-4,4,4-trifluorobutyl]benzoyl}-β-alanine
LY2409021
UNII-74Z5ZL2KVG

Biological Activity

[Description]:

Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Li Y et al. Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Org Lett. 2015 May 1;17(9):2186-9.

[2]. Kazda CM et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care. 2016 Jul;39(7):1241-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
656.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₃₆F₃NO₄

[ Molecular Weight ]:
555.628

[ Flash Point ]:
350.9±31.5 °C

[ Exact Mass ]:
555.259644

[ LogP ]:
7.53

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Storage condition ]:
2-8℃