1488363-78-5

1488363-78-5 structure

Name: Adomeglivant
Chemical Name: Adomeglivant
CAS Number: 1488363-78-5
Molecular Formula: C₃₂H₃₆F₃NO₄
Molecular Weight: 555.628
Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
Create Date: 2018-10-17 18:27:45
Modify Date: 2025-08-26 20:27:58
Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus.

Name	Adomeglivant
Synonyms	3-(4-{(1S)-1-[(4'-tert-butyl-2,6-dimethylbiphenyl-4-yl)oxy]-4,4,4-trifluorobutyl}benzamido)propanoic acid adomeglivant UNII:74Z5ZL2KVG 74Z5ZL2KVG β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]- N-{4-[(1S)-1-{[2,6-Dimethyl-4'-(2-methyl-2-propanyl)-4-biphenylyl]oxy}-4,4,4-trifluorobutyl]benzoyl}-β-alanine LY2409021 UNII-74Z5ZL2KVG

Description	Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor Research Areas >> Metabolic Disease
References	[1]. Li Y et al. Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Org Lett. 2015 May 1;17(9):2186-9. [2]. Kazda CM et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care. 2016 Jul;39(7):1241-9.