SRT3657

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].

Signaling Pathways >> Epigenetics >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Neurological Disease

SIRT1[1]

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1]. SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1]. SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1]. Animal Model: Adult double-transgenic CK-p25 mice (3-month-old)[1] Dosage: 30 mg/kg Administration: Oral gavage, daily, for 6 weeks Result: Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.

[1]. Gräff J, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013 May 22;33(21):8951-60.