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1383551-17-4

1383551-17-4 structure
1383551-17-4 structure
  • Name: SRT3657
  • Chemical Name: SRT3657
  • CAS Number: 1383551-17-4
  • Molecular Formula: C40H54N8O6S
  • Molecular Weight: 774.97
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
  • Create Date: 2020-06-01 22:08:08
  • Modify Date: 2024-02-12 21:33:56
  • SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].
Name SRT3657
Description SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].
Related Catalog
Target

SIRT1[1]
In Vivo SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1]. SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1]. SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1]. Animal Model: Adult double-transgenic CK-p25 mice (3-month-old)[1] Dosage: 30 mg/kg Administration: Oral gavage, daily, for 6 weeks Result: Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
References

[1]. Gräff J, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013 May 22;33(21):8951-60.
Molecular Formula C40H54N8O6S
Molecular Weight 774.97

Chemsrc provides CAS#:1383551-17-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 1383551-17-4 | Chemsrc address: https://www.chemsrc.com/en/baike/1565823.html

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