H-PRO-PHE-OH

Names

[ Name ]:
H-PRO-PHE-OH

[Synonym ]:
H-L-Pro-L-Phe-OH
N-L-Prolyl-L-phenylalanine
PRO-PHE
L-Pro-L-Phe-OH
pro-phecrystalline
Pro-Phe-OH
l-pro-l-phe
L-Prolyl-L-phenylalanine
L-Phenylalanine, L-prolyl-
PROLINE-PHENYLALANINE

Biological Activity

[Description]:

H-Pro-Phe-OH is a dipeptide containing proline and phenylalanine, which can serve as a substrate for prolinase. H-Pro-Phe-OH can also be used for polypeptide synthesis, where phenylalanine is an aromatic amino acid that can inhibit the activity of Angiotensin-converting enzyme (ACE, HY-P2983)[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[References]

[1]. Majumder K, et al. Angiotensin I converting enzyme inhibitory peptides from simulated in vitro gastrointestinal digestion of cooked eggs. J Agric Food Chem. 2009 Jan 28;57(2):471-7.

[2]. Priestman DA, et al. Prolinase and non-specific dipeptidase of human kidney. Biochem J. 1985 Nov 1;231(3):689-94.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
531.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₈N₂O₃

[ Molecular Weight ]:
262.30

[ Flash Point ]:
275.5±30.1 °C

[ Exact Mass ]:
262.131744

[ PSA ]:
78.43000

[ LogP ]:
0.67

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.568

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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