Longdaysin

Names

[ Name ]:
Longdaysin

Biological Activity

[Description]:

Longdaysin is a CK1α, CK1δ, and extracellular signal-regulated kinase 2 (ERK2) inhibitor with IC50s of 5.6 µM, 8.8 µM, and 52 µM, respectively[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

CKIα:5.6 μM (IC50)

CKIδ:8.8 μM (IC50)

ERK2:52 μM (IC50)

[References]

[1]. 1. Griffett K, et al. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7):1929-1934..

[2]. Hirota T, et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₆F₃N₅

[ Molecular Weight ]:
335.33

[ Storage condition ]:
2-8℃

Related Compounds

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