1353867-91-0

1353867-91-0 structure

Name: Longdaysin
Chemical Name: Longdaysin
CAS Number: 1353867-91-0
Molecular Formula: C₁₆H₁₆F₃N₅
Molecular Weight: 335.33
Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
Create Date: 2019-06-01 18:02:56
Modify Date: 2024-01-09 16:35:07
Longdaysin is a CK1α, CK1δ, and extracellular signal-regulated kinase 2 (ERK2) inhibitor with IC50s of 5.6 µM, 8.8 µM, and 52 µM, respectively[1][2].

Name	Longdaysin

Description	Longdaysin is a CK1α, CK1δ, and extracellular signal-regulated kinase 2 (ERK2) inhibitor with IC50s of 5.6 µM, 8.8 µM, and 52 µM, respectively[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	CKIα:5.6 μM (IC50) CKIδ:8.8 μM (IC50) ERK2:52 μM (IC50)
References	[1]. 1. Griffett K, et al. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7):1929-1934.. [2]. Hirota T, et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.