β-Glycerol phosphate disodium salt pentahydrate

Names

[ Name ]:
β-Glycerol phosphate disodium salt pentahydrate

[Synonym ]:
β-Glycerophosphoric Acid Disodium Salt Pentahydrate
1,2,3-Propanetriol, 2-(dihydrogen phosphate), sodium salt (1:2)
Disodium 1,3-dihydroxypropan-2-yl phosphate
beta-Glycerophosphoric acid
Sodium 1,3-dihydroxypropan-2-yl phosphate
sodium glycerol 2-phosphate
MFCD00149083
Disodium 1,3-dihydroxy-2-propanyl phosphate
disodium,1,3-dihydroxypropan-2-yl phosphate,pentahydrate
EINECS 212-464-3
Disodium β-Glycerophosphate Pentahydrate
β-Glycerol phosphate disodium salt pentahydrate

Biological Activity

[Description]:

β-Glycerol phosphate disodium salt pentahydrate is a Phosphatase and tensin homolog (PTEN) inhibitor extracted from patent US 20110002877 A1.

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> PTEN

Research Areas >> Cancer

Research Areas >> Neurological Disease

[Target]

Phosphatase and tensin homolog (PTEN)[1]

[References]

[1]. Hongbo R. Luo, et al. PTEN Inhibitors Treat Neutropenia-Associated Pneumonia. US 20110002877 A1.

[Related Small Molecules]

VO-Ohpic trihydrate | SF1670

Chemical & Physical Properties

[ Boiling Point ]:
488.2ºC at 760mmHg

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₃H₁₉Na₂O₁₁P

[ Molecular Weight ]:
308.13

[ Flash Point ]:
249.1ºC

[ PSA ]:
111.69000

[ LogP ]:
0.28450

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 0.1 g/mL, clear, colorless | Soluble in water.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UA0600000

[ HS Code ]:
2919900090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2919900090

[ Summary ]:
2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.

Mol. Cancer 13 , 259, (2014)

Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PI...

Polyubiquitin chain-dependent protein degradation in TRIM30 cytoplasmic bodies.

Exp. Mol. Med. 47 , e159, (2015)

Viral infection induces numerous tripartite motif (TRIM) proteins to control antiviral immune signaling and viral replication. Particularly, SPRY-containing TRIM proteins are found only in vertebrates...

Human mesenchymal stem cells as a novel platform for simultaneous evaluation of cytotoxicity and genotoxicity of pharmaceuticals.

Mutagenesis 30 , 391-9, (2015)

The in vitro micronucleus test is a well-known test for the screening of genotoxic compounds. However until now, most studies have been performed on either human peripheral lymphocytes or established ...