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Compound L

Names

[ CAS No. ]:
1326852-06-5

[ Name ]:
Compound L

Biological Activity

[Description]:

STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK
Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK

[Target]

IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]


[References]

[1]. Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H20FN5O4

[ Molecular Weight ]:
437.42

Related Compounds