DC Chemicals Limited
China
Product Name: Compound L
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1326852-06-5

1326852-06-5 structure

1326852-06-5 structure

Name: Compound L
Chemical Name: STL127705
CAS Number: 1326852-06-5
Molecular Formula: C₂₂H₂₀FN₅O₄
Molecular Weight: 437.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA-PK
Create Date: 2019-06-01 19:09:10
Modify Date: 2024-01-12 08:43:33
STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].

Name	STL127705

Description	STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]
References	[1]. Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.

Molecular Formula	C₂₂H₂₀FN₅O₄
Molecular Weight	437.42