Tazomeline

Names

[ CAS No. ]:
131987-54-7

[ Name ]:
Tazomeline

[Synonym ]:
Tazomeline [INN]
(3-Hexylthio)-tztp
UNII-QDP6S14W5W
Tazomeline
3-(3-Hexylthio-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine
3-(4-hexylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine

Biological Activity

[Description]:

Tazomeline is a selective M1 muscarinic receptor agonist. Tazomeline inhibits twitch height in rabbit vas deferens(IC50= 0.001 nM). Tazomeline can be used for research of neuropsychiatric disorders[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. Sauerberg P, et al. Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . J Med Chem. 1992 Jun 12;35(12):2274-83.

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
407.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₂₃N₃S₂

[ Molecular Weight ]:
297.48300

[ Flash Point ]:
200.4ºC

[ Exact Mass ]:
297.13300

[ PSA ]:
82.56000

[ LogP ]:
3.86730

[ Vapour Pressure ]:
7.36E-07mmHg at 25°C

[ Index of Refraction ]:
1.58

Precursor & DownStream

Precursor

DownStream

Related Compounds

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