PKR-IN-C51

Names

[ Name ]:
PKR-IN-C51

Biological Activity

[Description]:

PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Infection

[Target]

IC50: 9 μM (double-stranded RNA-activated protein kinase (PKR))[1]

[References]

[1]. Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁N₅

[ Molecular Weight ]:
367.45

Related Compounds

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