1314594-23-4

1314594-23-4 structure

Name: PKR-IN-C51
Chemical Name: PKR-IN-C51
CAS Number: 1314594-23-4
Molecular Formula: C₂₃H₂₁N₅
Molecular Weight: 367.45
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2022-08-22 11:30:36
Modify Date: 2024-01-06 18:04:34
PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1].

Name	PKR-IN-C51

Description	PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Infection
Target	IC50: 9 μM (double-stranded RNA-activated protein kinase (PKR))[1]
References	[1]. Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14.

Molecular Formula	C₂₃H₂₁N₅
Molecular Weight	367.45