LY 2812223

Names

[ Name ]:
LY 2812223

Biological Activity

[Description]:

LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu2 (Ki=144 nM and 156 nM, respectively)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR2:144 nM (Ki)

mGluR3:156 nM (Ki)

[References]

[1]. Monn JA, et al. Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58(18):7526-48.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₂N₄O₄S

[ Molecular Weight ]:
284.29

Related Compounds

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