Dapoxetine Hydrochloride

Names

[ Name ]:
Dapoxetine Hydrochloride

[Synonym ]:
(1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine hydrochloride (1:1)
(1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine hydrochloride
ly 210448 hydrochloride
(S)-N,N-Dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine Hydrochloride
(1S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride
(1S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-aminhydrochlorid
(1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine hydrochloride (1:1)
Dapoxetine HCl
Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, (αS)-, hydrochloride (1:1)
(+)-(S)-N,N-Dimethyl-α-(2-(1-naphthyloxy)ethyl)benzylamine hydrochloride
(1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine,hydrochloride
MFCD08272809
Benzenemethanamine, N,N-dimethyl-α-(2-(1-naphthalenyloxy)ethyl)-, hydrochloride, (αS)-
(S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride
(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride

Biological Activity

[Description]:

Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).Target: SSRIDapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. Dapoxetine is the only drug with regulatory approval for such an indication. The treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitors (SSRIs) via either on-demand or daily delivery.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

Research Areas >> Neurological Disease

[References]

[1]. McMahon CG. Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol. 2012 Oct;4(5):233-51.

[2]. Dapoxetine, From Wikipedia, the free encyclopedia

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
454.4ºC at 760 mmHg

[ Melting Point ]:
175-179ºC

[ Molecular Formula ]:
C₂₁H₂₄ClNO

[ Molecular Weight ]:
341.874

[ Flash Point ]:
132.6ºC

[ Exact Mass ]:
341.154633

[ PSA ]:
12.47000

[ LogP ]:
5.71360

[ Vapour Pressure ]:
1.27E-09mmHg at 25°C

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H413

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-36-50/53

[ Safety Phrases ]:
36-60-61

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

New insights on premature ejaculation: a review of definition, classification, prevalence and treatment.

Asian J. Androl. 14(6) , 822-9, (2012)

There are ongoing debates about the definition, classification and prevalence of premature ejaculation (PE). The first evidence-based definition of PE was limited to heterosexual men with lifelong PE ...

Chiral recognition of dapoxetine enantiomers with methylated-gamma-cyclodextrin: a validated capillary electrophoresis method.

J. Pharm. Biomed. Anal. 62 , 42-7, (2012)

The enantiomers of dapoxetine, a serotonin transporter inhibitor for the treatment of premature ejaculation have been separated by cyclodextrin modified capillary zone electrophoresis using uncoated f...

Dapoxetine for premature ejaculation.

Expert Opin. Pharmacother. 11(10) , 1741-52, (2010)

Premature ejaculation (PE) is a common male sexual disorder which is associated with substantial personal and interpersonal negative psychological factors. Drug treatment of PE with an off-label antid...