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Vilazodone Hydrochloride

Names

[ CAS No. ]:
163521-08-2

[ Name ]:
Vilazodone Hydrochloride

[Synonym ]:
Vilazodone HCl
2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1)
Vilazodone hydrochloride
vilazodone monohydrochloride
Vilazodone (Hydrochloride)
Viibryd
5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-1-benzofuran-2-carboxamide hydrochloride (1:1)
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide,hydrochloride
UNII-U8HTX2GK8J

Biological Activity

[Description]:

Vilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
Research Areas >> Neurological Disease

[Target]

5-HT1A Receptor


[In Vivo]

Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone (55 mg/kg po) at 120 and 210 min post dose. Vilazodone (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone also represents another option for the treatment of MDD[2].

[References]

[1]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009

[2]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME.The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder.Curr Med Res Opin. 2012 Jan;28(1):27-39.


[Related Small Molecules]

Fluoxetine Hydrochloride | Harmine | Pimavanserin | Paroxetine HCl | Serotonin hydrochloride | Sodium Ferulate | Sertraline hydrochloride | Thioridazine hydrochloride | Brexpiprazole | Fluvoxamine maleat | Risperidone | TG6-10-1 | Cariprazine | Duloxetine hydrochloride | Quetiapine

Chemical & Physical Properties

[ Boiling Point ]:
745.1ºC at 760 mmHg

[ Melting Point ]:
279°C(lit.)

[ Molecular Formula ]:
C26H28ClN5O2

[ Molecular Weight ]:
477.98600

[ Flash Point ]:
404.4ºC

[ Exact Mass ]:
477.19300

[ PSA ]:
103.28000

[ LogP ]:
5.71868

[ Appearance of Characters ]:
white to beige

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: soluble20mg/mL, clear

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Related Compounds