MCH(human, mouse, rat)

Names

[ Name ]:
MCH(human, mouse, rat)

[Synonym ]:
MFCD00080193
Melanin Concentrating Hormone,human,mouse
Melanin concentrating hormone,human,mouse,rat

Biological Activity

[Description]:

MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24)

Research Areas >> Neurological Disease

[Target]

Binding IC50: 0.3 nM (MCH1R) IC50: 1.5 nM (MCH1R)[1]

[References]

[1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₅H₁₆₀N₃₀O₂₆S₄

[ Molecular Weight ]:
2386.84000

[ Exact Mass ]:
2385.10000

[ PSA ]:
1018.94000

[ LogP ]:
6.54720

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.

Nat. Cell Biol. 12 , 267-271, (1999)

Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we i...

Molecular characterization of the melanin-concentrating-hormone receptor.

Nature 400 , 265-269, (1999)

Orphan G-protein-coupled receptors (GPCRs) are cloned proteins with structural characteristics common to the GPCRs but that bind unidentified ligands. Orphan GPCRs have been used as targets to identif...

Investigation of the feeding effects of melanin concentrating hormone on food intake--action independent of galanin and the melanocortin receptors.

Brain Res. 846 , 164-170, (1999)

Melanin concentrating hormone (MCH) is recognised as a hypothalamic appetite stimulant. The mechanism of action of MCH is undetermined largely due to lack of identification of hypothalamic MCH recepto...