Conantokin-T

Names

[ Name ]:
Conantokin-T

[Synonym ]:
Conatokin t

Biological Activity

[Description]:

Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

IC50: 2 μM (NMDA)[1]

[In Vitro]

Conantokin-T produces a partial antagonism of NMDA receptor function with an IC50 value of 2 μM[1].

[In Vivo]

Conantokin-T induces sleep-like symptoms in young mice[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁₀H₁₇₅N₃₁O₄₅S

[ Molecular Weight ]:
2683.81000

[ Exact Mass ]:
2682.21000

[ PSA ]:
1338.87000

[ LogP ]:
0.32530

Related Compounds

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