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Galanin (1-16) (mouse, porcine, rat)

Names

[ CAS No. ]:
125118-77-6

[ Name ]:
Galanin (1-16) (mouse, porcine, rat)

[Synonym ]:
Galanin (pig),17-de-L-aspartic acid-18-de-L-asparagine-19-de-L-histidine-20-de-L-arginine-21-de-L-serine-22-de-L-phenylalanine-23-de-L-histidine-24-de-L-aspartic acid-25-de-L-lysine-26-de-L-tyrosine-27-deglycine-28-de-L-leucine-29-de-L-alaninamide
GALANIN (1-16) (PORCINE,RAT)
Galanin (1-16), mouse, porcine, rat

Biological Activity

[Description]:

Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Research Areas >> Neurological Disease
Peptides

[Target]

Kd: 3 nM (Galanin receptor)[1]


[In Vitro]

Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM[1]. Galanin (1-16), mouse, porcine, rat shows high biological activity on locus coeruleus neurons[2].

[References]

[1]. Fisone G, et al. N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9588-91.

[2]. Hilke S, et al. A short estrogen-responsive N-terminal galanin homologue found in rat brain and gut with antiserum raised against rat galanin(1-16). Neurochem Res. 2006 Feb;31(2):177-88.


[Related Small Molecules]

Velneperit | MK 0557 | HT-2157 | BIIE 0246 | JNJ-31020028 | CGP 71683 HCl | FR252384 | Galanin (human) acetate salt | Galanin (1-13)-Substance P (5-11) amide | Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide | Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt | Neuropeptide Y(29-64) | Pancreatic Polypeptide, bovine

Chemical & Physical Properties

[ Molecular Formula ]:
C78H116N20O21

[ Molecular Weight ]:
1669.88000

[ Exact Mass ]:
1668.86000

[ PSA ]:
639.28000

[ LogP ]:
1.99260

Related Compounds