Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide

M40 is a potent, non-selective galanin receptor antagonist.

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

Peptides

Research Areas >> Others

M40 (1 μM) displaces [mono[125IJodo-Tyr26]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC50 values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks 125I-labeled galanin-binding sites[1].

[1]. Bartfai T, et al. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11287-91.

Velneperit | MK 0557 | HT-2157 | BIIE 0246 | Galanin (1-16) (mouse, porcine, rat) | JNJ-31020028 | CGP 71683 HCl | FR252384 | Galanin (human) acetate salt | Galanin (1-13)-Substance P (5-11) amide | Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt | Neuropeptide Y(29-64) | Pancreatic Polypeptide, bovine | Pancreatic Polypeptide (human) trifluoroacetate salt