Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt

Names

[ Name ]:
Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt

[Synonym ]:
MFCD02099923

Biological Activity

[Description]:

Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system[1][2][3].

[Related Catalog]:

Research Areas >> Endocrinology

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

NPY Y2 receptor

[In Vitro]

Peptide YY (pig) (10 μg/mL) 和人类胰多肽 (PP) 一样具有抗体特异性，即对 PYY 抗血清特异，两者都可能在各种脊椎动物胰岛激素分泌的调节中发挥内分泌或旁分泌作用[2]。

[In Vivo]

Peptide YY1-36 (pig) 会被二肽基肽酶 IV (DPP-IV) 降解为 PYY3-36。PYY3-36 (50 nmol/kg; 静脉注射; 单剂量) 在哥根廷迷你猪和恒河猴中会进一步分解为许多代谢产物[3]。 Peptide YY1-36 (pig) 具有减缓肠道转运、抑制胃肠道负离子和电解质分泌、降低血糖等其他生理作用[3]。

[References]

[1]. Lundberg JM, et al. Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc Natl Acad Sci U S A. 1982 Jul;79(14):4471-5.

[2]. Ding WG, et al. Neuropeptide Y and peptide YY immunoreactivities in the pancreas of various vertebrates. Peptides. 1997;18(10):1523-9.

[3]. Olsen J, et al. Metabolism of peptide YY 3-36 in Göttingen mini-pig and rhesus monkey. Peptides. 2016 Apr;78:59-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉₀H₂₈₈N₅₄O₅₇

[ Molecular Weight ]:
4240.65

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0