Glucocorticoid receptor agonist
Names
[ CAS No. ]:
1245526-82-2
[ Name ]:
Glucocorticoid receptor agonist
[Synonym ]:
Glucocorticoid receptor agonist
CS-0520
Biological Activity
[Description]:
Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.IC50 value:Target:
[Related Catalog]:
[Animal admin]
Animal administration [1]Female Balb/c mice weighing approximately 20 g were used. Mice were administered the test compound and in Cremophor (po) approximately 60 min prior to LPS/D-gal administration. The volume of oral gavage was 0.15 mL. Then mice were administered LPS (E. coli LPS 055:85, 1.0 μg/mouse) plus D-gal (50 mg/kg) intravenously in 0.2 mL of pyrogen-free saline. One hour after LPS/D-gal, each mouse was anesthetized, bled by cardiac puncture, and collected for serum TNF-R and compound levels. Blood samples were centrifuged at 2500 rpm for 10-15 min, the serum was decanted, and samples were stored frozen at -70°C until transfer either for TNF-R determination or to Drug Metabolism and Pharmacokinetics for plasma concentration analysis by HPLC. The concentration of TNF-R in the serum was measured by a commercially available ELISA kit. ELISA was performed. All samples are assayed in duplicate.
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H20F4N2O2
[ Molecular Weight ]:
396.37900
[ Exact Mass ]:
396.14600
[ PSA ]:
69.14000
[ LogP ]:
4.61140
[ Storage condition ]:
2-8℃