Stearic acid amide

Names

[ CAS No. ]:
124-26-5

[ Name ]:
Stearic acid amide

[Synonym ]:
Octadecamide
stearic amide
Octadecanamide
stearylamide
distearyl amide
Octadecylamide
STEARIC ACID AMIDE
EINECS 204-693-2
Stearoylamide
stearoylamine
Stearamide
MFCD00008038

Biological Activity

[Description]:

Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Matthew J.Bertin, et al. Identification of toxic fatty acid amides isolated from the harmful alga Prymnesium parvum carter.

Chemical & Physical Properties

[ Density]:
0.868 g/cm3

[ Boiling Point ]:
250-251 °C12 mm Hg(lit.)

[ Melting Point ]:
98-102 °C(lit.)

[ Molecular Formula ]:
C₁₈H₃₇NO

[ Molecular Weight ]:
283.49200

[ Flash Point ]:
207.5ºC

[ Exact Mass ]:
283.28800

[ PSA ]:
43.09000

[ LogP ]:
6.43350

[ Vapour Pressure ]:
7.11E-07mmHg at 25°C

[ Index of Refraction ]:
1.432-1.434

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG0182000

CHEMICAL NAME :: Octadecanamide

CAS REGISTRY NUMBER :: 124-26-5

BEILSTEIN REFERENCE NO. :: 0909006

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H37-N-O

MOLECULAR WEIGHT :: 283.56

WISWESSER LINE NOTATION :: ZV17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,105,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4134 No. of Facilities: 119 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 1994 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4134 No. of Facilities: 529 (estimated) No. of Industries: 11 No. of Occupations: 20 No. of Employees: 23611 (estimated) No. of Female Employees: 11289 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
RG0182000

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma.

J. Pharm. Biomed. Anal. 104 , 1-11, (2014)

MTH1 is a protein that is required for cancer cell survival and is overexpressed in cancer cells. TH588 and TH287 are two new compounds that inhibit the MTH1 protein. The inhibitors were tested in pha...

Related Compounds

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