CGP 36742

Names

[ Name ]:
CGP 36742

[Synonym ]:
3-aminopropyl-(n-butyl)-phosphinic acid
(3-amino-propyl)-butyl-phosphinic acid
(3-aminopropyl)(n-butyl)phosphinic acid
3-amino-propyl-n-butyl-phosphinic acid

Biological Activity

[Description]:

CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

IC50: 32 μM (GABAB)[1]

[References]

[1]. Nowak G, et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149(5):581-90.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₈NO₂P

[ Molecular Weight ]:
179.19700

[ Exact Mass ]:
179.10800

[ PSA ]:
73.13000

[ LogP ]:
2.10600

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
SZ4113300

Related Compounds

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