Mycalolide B

Names

[ Name ]:
Mycalolide B

[Synonym ]:
mycalolides B
4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C
Mycalolide B,Mycale sp.

Biological Activity

[Description]:

Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

actomyosin ATPase[1]

[In Vitro]

Mycalolide-B belongs to macrolide antibiotics and consists of tris-oxazole with strong cytotoxic activity (IC50: 10-50 nM for growth of L1210 murine leukemia cells). Mycalolide-B, a toxin isolated from marine sponge, inhibits smooth muscle contractions without changing cytosolic Ca2+ levels. Mycalolide-B also inhibits Ca2+-induced contraction in permeabilized smooth muscles. Mycalolide-B inhibits superprecipitation and Mg2+-ATPase activity stimulated by Ca2+ without changing myosin light chain phosphorylation. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].

[References]

[1]. Hori M, et al. Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge. FEBS Lett. 1993;322(2):151-154.

Chemical & Physical Properties

[ Density]:
1.23 g/cm3

[ Boiling Point ]:
1042.3ºC at 760 mmHg

[ Molecular Formula ]:
C₅₂H₇₄N₄O₁₇

[ Molecular Weight ]:
1027.16000

[ Flash Point ]:
584.2ºC

[ Exact Mass ]:
1026.50000

[ PSA ]:
260.75000

[ LogP ]:
7.39070

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.548

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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