Thonningianin B

Thonningianin B is an antioxidant and an autophagy enhancer[1][2].

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

Thonningianin B 对 DPPH 自由基有较强的清除作用。34.5 μM 的 Thonningianin B 溶液可以完全清除 DPPH 自由基。在另一个实验中，Thonningianin B 的 IC50 值为 21 μM[1]。 Thonningianin B (0-100 μM; 24 h) 抑制 BV-2 细胞活力，IC50 为 46.74 μM[2]。 Thonningianin B (10 μM;24 h) 显著提高了 BV-2 细胞中 LC3-II/LC3-I 的比例和每个细胞平均 GFP-LC3 点数[2]。 Cell Viability Assay[2] Cell Line: BV-2 cells Concentration: 0-100 μM Incubation Time: 24 h Result: Inhibited viability with an IC50 of 46.74 μM. Cell Autophagy Assay[2] Cell Line: BV-2 cells Concentration: 10 μM Incubation Time: 24 h Result: Significantly improved the ratio of LC3-II/LC3-I and the average number of GFP-LC3 puncta per cell.

[1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9.  

[2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflamm Regen. 2022 Aug 3;42(1):25.