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SK1-IN-1

Names

[ CAS No. ]:
1218816-71-7

[ Name ]:
SK1-IN-1

[Synonym ]:
(3S)-N-[(1S)-1-{4-[5-(2-Cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl}ethyl]-3-hydroxy-L-prolinamide
2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)-

Biological Activity

[Description]:

SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> SPHK
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[Target]

IC50: 58 nM (SPHK1)[1]


[In Vivo]

SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1].

[References]

[1]. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4.


[Related Small Molecules]

ABC294640 | K145 (hydrochloride) | PF-543 (Citrate) | SKI II | MHP | MP A08

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C22H30N4O3

[ Molecular Weight ]:
398.499

[ Exact Mass ]:
398.231781

[ LogP ]:
2.39

[ Index of Refraction ]:
1.571

[ Storage condition ]:
2-8℃

Related Compounds