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SMS1-IN-1

Names

[ CAS No. ]:
1807943-38-9

[ Name ]:
SMS1-IN-1

Biological Activity

[Description]:

SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: 2.1 μM (SMS1)[1]


[In Vitro]

SMS1-IN-1 (2.5, 10 and 50 μM) has a dose-dependent inhibitory effect against SMS1, and is against SMS1 with an IC50 value of 2.1 μM[1].

[References]

[1]. Li YL, et al. Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.Bioorg Med Chem. 2015 Sep 15;23(18):6173-84.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23BrN2O4S

[ Molecular Weight ]:
503.41

Related Compounds