SIRT6-IN-1

Names

[ Name ]:
SIRT6-IN-1

[Synonym ]:
2,4-Dioxo-N-[4-(3-pyridinyloxy)phenyl]-1,2,3,4-tetrahydro-6-quinazolinesulfonamide
6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]-
MFCD11667663

Biological Activity

[Description]:

SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Signaling Pathways >> Epigenetics >> Histone Demethylase

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Metabolic Disease

[Target]

106 μM and 114 μM (SIRT6/SIRT2)[1]

[References]

[1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₁₄N₄O₅S

[ Molecular Weight ]:
410.40

[ Exact Mass ]:
410.068481

[ LogP ]:
1.88

[ Index of Refraction ]:
1.674

SIRT6-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds