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CaMKII-IN-1

Names

[ CAS No. ]:
1208123-85-6

[ Name ]:
CaMKII-IN-1

[Synonym ]:
N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide
Benzenesulfonamide, 3-chloro-2-methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)amino]-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]-
CaMKII-IN-1

Biological Activity

[Description]:

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.IC50 value: 63 nMTarget: CaMKII

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> CaMK
Research Areas >> Inflammation/Immunology

[References]

[1]. Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8.


[Related Small Molecules]

KN-93 | STO609 | KN-62 | KN-92-hydrochloride | MLCK inhibitor peptide 18 | Autocamtide-2 | A 484954 | Rimacalib | Calmodulin-Dependent Protein Kinase II (290-309) | Metofenazate | NH 125 | Syntide 2 trifluoroacetate salt

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
728.2±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H30ClN5O2S

[ Molecular Weight ]:
548.09900

[ Flash Point ]:
394.2±35.7 °C

[ Exact Mass ]:
547.18100

[ PSA ]:
95.60000

[ LogP ]:
5.48

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.670

[ Storage condition ]:
2-8℃

Related Compounds