Nudifloramide-d3

Names

[ CAS No. ]:
1207384-48-2

[ Name ]:
Nudifloramide-d3

[Synonym ]:
6-oxo-1-(trideuteriomethyl)pyridine-3-carboxamide

Biological Activity

[Description]:

Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP

Research Areas >> Metabolic Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Rutkowski B, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl. 2003 May;(84):S19-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₅D₃N₂O₂

[ Molecular Weight ]:
155.16900

[ Exact Mass ]:
155.07700

[ PSA ]:
66.08000

[ LogP ]:
0.36840

Related Compounds

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