WAY208466 dihydrochloride

Names

[ CAS No. ]:
1207064-61-6

[ Name ]:
WAY208466 dihydrochloride

[Synonym ]:
MFCD20926423
2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-1-yl}-N,N-dimethylethanamine dihydrochloride
WAY 208466 dihydrochloride
WAY-208466 (hydrochloride)
1H-Pyrrolo[2,3-b]pyridine-1-ethanamine, 3-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-, hydrochloride (1:2)
WAY-208466 DIHYDROCHLORIDE

Biological Activity

[Description]:

WAY 208466 dihydrochloride is a potent and selective 5-HT6 receptor agonist (EC50=7.3 nM for the human 5-HT6 receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex[1]. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35.

[2]. Carr GV, Schechter LE, Lucki I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology (Berl). 2011 Feb;213(2-3):499-507.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₀Cl₂FN₃O₂S

[ Molecular Weight ]:
420.329

[ Exact Mass ]:
419.063721

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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