preQ1 Dihydrochloride

Names

[ Name ]:
preQ1 Dihydrochloride

[Synonym ]:
7-aminomethyl-7-deazaguanine dihydrochloride
preQ1 Dihydrochloride

Biological Activity

[Description]:

preQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine (HY-N10574) biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Connelly CM, et al. Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun. 2019 Apr 2;10(1):1501.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₀ClN₅O

[ Molecular Weight ]:
215.64000

[ Exact Mass ]:
215.05700

[ PSA ]:
113.58000

[ LogP ]:
1.37560

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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