SRT3109

Names

[ CAS No. ]:
1204707-71-0

[ Name ]:
SRT3109

[Synonym ]:
Y0301
CS-0977
1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]-
SRT-3109
cc-200
N-(2-[(2,3-Difluorobenzyl)sulfanyl]-6-{[(2R,3R)-3,4-dihydroxy-2-butanyl]amino}-4-pyrimidinyl)-1-azetidinesulfonamide
SRT3109

Biological Activity

[Description]:

SRT3109 is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

CXCR2:8.2 (pIC50)

[In Vitro]

SRT3109 (Example 1) is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases[1].

[References]

[1]. Premji Meghani, et al. Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases. WO2010007427A1

[Related Small Molecules]

Reparixin | AMG 487 | SCH 527123 | SB 225002 | AZD-5069 | LY2510924 | SCH 546738 | TAK-779 | BKT140 acetate salt | Danirixin | AZD8797 | Baohuoside I | SCH 563705 | IT1t dihydrochloride

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
726.6±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₃F₂N₅O₄S₂

[ Molecular Weight ]:
475.533

[ Flash Point ]:
393.3±35.7 °C

[ Exact Mass ]:
475.115936

[ PSA ]:
161.36000

[ LogP ]:
2.07

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.661

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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