<Suppliers Price>

AZD-5069

Names

[ CAS No. ]:
878385-84-3

[ Name ]:
AZD-5069

[Synonym ]:
1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-
N-(2-[(2,3-Difluorobenzyl)sulfanyl]-6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-4-pyrimidinyl)-1-azetidinesulfonamide

Biological Activity

[Description]:

AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR
Signaling Pathways >> Immunology/Inflammation >> CXCR
Research Areas >> Cancer

[Target]

125I-IL-8-CXCR2


[In Vitro]

AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of [125I]-IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye[1].

[References]

[1]. Norman P. Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opin Ther Pat. 2013 Jan;23(1):113-7.


[Related Small Molecules]

Reparixin | AMG 487 | SCH 527123 | SB 225002 | LY2510924 | SCH 546738 | TAK-779 | BKT140 acetate salt | Danirixin | AZD8797 | Baohuoside I | SCH 563705 | IT1t dihydrochloride | MSX-122

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
680.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H22F2N4O5S2

[ Molecular Weight ]:
476.518

[ Flash Point ]:
365.4±34.3 °C

[ Exact Mass ]:
476.099976

[ LogP ]:
2.43

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
2-8℃

Related Compounds