Danirixin

Names

[ Name ]:
Danirixin

[Synonym ]:
Urea, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-
1-{4-Chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-3-(3-fluoro-2-methylphenyl)urea
Danirixin
GSK1325756

Biological Activity

[Description]:

Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

Research Areas >> Inflammation/Immunology

[Target]

CXCL8-CXCR2:12.5 nM (IC50)

[In Vitro]

Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine[1].

[References]

[1]. Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist?--in healthy adult subjects. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.

[Related Small Molecules]

Reparixin | AMG 487 | SCH 527123 | SB 225002 | AZD-5069 | LY2510924 | SCH 546738 | TAK-779 | BKT140 acetate salt | AZD8797 | Baohuoside I | SCH 563705 | IT1t dihydrochloride | MSX-122

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
533.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₁ClFN₃O₄S

[ Molecular Weight ]:
441.904

[ Flash Point ]:
276.2±30.1 °C

[ Exact Mass ]:
441.092529

[ LogP ]:
3.93

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
2-8℃